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A study of how seated or supine posture during docetaxel infusion affects lower-limb water content in patients with breast cancer

Effect of seated vs supine posture during docetaxel infusion on left lower-limb extracellular water and clinical edema in patients with breast cancer: a single-center, parallel-group, open-label, exploratory randomized controlled trial - DTX-POSTURE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000057809
Enrollment
30
Registered
2025-05-09
Start date
2025-01-06
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Interventions

Seated group: After randomization, participants receive docetaxel infusion in a seated position in a reclining chair during all 4 cycles of docetaxel therapy. The backrest angle may be adjusted for pa

Sponsors

Fujita Health University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: -Patients who have received sufficient explanation and provided written informed consent voluntarily -Patients who are 18 years or older at the time of consent

Exclusion criteria

Exclusion criteria: Patients will be excluded if they meet any of the following conditions: -Presence of lower limb lymphedema -Diagnosed with conditions that may cause edema: Deep vein thrombosis of the lower limbs Severe cardiac or pulmonary disease Severe hepatic or renal dysfunction Other metabolic disorders -Implanted pacemaker -Unable to maintain posture required for ultrasound examination -Any other reason deemed inappropriate by the principal or co-investigators Rationale: To exclude confounding causes of edema and ensure safety and data validity.

Design outcomes

Primary

MeasureTime frame
Body composition

Secondary

MeasureTime frame
Incidence of edema

Countries

Japan

Contacts

Public ContactNagae KAWASUSO

Fujita Health University Faculty of Nursing, School of Health Sciences

nagae.kawasuso@fujita-hu.ac.jp0562-93-9084

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026