Post operative nausea and vomiting
Conditions
Interventions
The allocated participant will orally take encapsulated crushed olanzapine (OD tablet) 5.0 mg two hours prior to surgery.
The allocated participant will take orally 300 mg of lactose with colored-pow
Sponsors
JA Yoshida General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Scheduled knee arthroplasty 2)Use of subarachnoid morphine 3)ASA-PS class 1 or 2 4) Age equals or under 80 5)Appel score more than 3
Exclusion criteria
Exclusion criteria: 1)Diabetic patient 2)Use of anti-psychotics (anxiolytics, sleep induction medications are excluded) 3)known allergy to trial drugs, opioids and anesthetics 4)Use of anti-emetics 24hrs before surgery 5)Inappropriate use of the drug of this trial due to conditions such as past or familial history of malignant syndrome and extrapyramidal symptoms. 6)Unable to consent or understand the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and frequency of nausea and vomiting, administration of rescue anti-emetics within 6-hrs, 6-12 hrs and 12-24hrs after the surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Food intake status on the morning and afternoon after surgery; frequency of use of analgesics outside of the clinical pathway; pain NRS (Numerical Rating Scale) scores; RASS (Richmond Agitation-Sedation Scale) score on the morning after surgery; wheelchair transfer assistance score on the day after surgery (as an indicator of rehabilitation progress); patient satisfaction; adverse events and their frequency. | — |
Countries
Japan
Contacts
Public ContactTsunehisa Namba
JA Yoshida General Hospital Department of Anesthesia
Outcome results
None listed