Study on the pathogenesis and progression mechanisms of type 1 diabetes using lymphocytes

Study on the pathogenesis and progression mechanisms of type 1 diabetes using peripheral blood lymphocytes - Lymphocyte-based study of type 1 diabetes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057687

Enrollment

Registered

2025-04-22

Start date

2025-04-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Individuals newly diagnosed with type 1 diabetes (including potential misdiagnoses) or those who are positive for islet-related autoantibodies but have not yet developed diabetes and are considered at risk for type 1 diabetes, who are aged 15 years or older at the time of consent/registration.

Exclusion criteria

Exclusion criteria: Individuals who are positive for islet-related autoantibodies but have diabetes with suspected alternative pathogenesis Individuals with severe infections or other serious comorbidities Individuals deemed unsuitable for participation in this study by the principal investigator or co-investigators

Design outcomes

Primary

Measure	Time frame
Activation enhancer regions and autoimmune-related genes in immune cells such as T cells that support the association with the onset and progression of type 1 diabetes	—

Secondary

Measure	Time frame
Association between HLA types and activation enhancer regions and autoimmune-related genes Association between islet-related autoantibodies and activation enhancer regions and autoimmune-related genes	—

Countries

Japan

Contacts

Public ContactHayao Yoshida

Graduate School of Medicine, Kyoto University Department of Diabetes, Endocrinology and Nutrition

hayayoshi@kuhp.kyoto-u.ac.jp075-751-3560

Outcome results