Using Endoscopic Oxygen Saturation Imaging to Predict the Efficacy and Prognosis of Radiotherapy for Head and Neck Cancer

Multicenter observational study of oxygen saturation imaging endoscopy for treatment selection based on chemoradiotherapy sensitivity and prognostic prediction of resectable locally advanced head and neck cancer - Multicenter Observational Study of Head and Neck Cancer with Oxygen Saturation Imaging Endoscopy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057661

Enrollment

100

Registered

2025-04-28

Start date

2023-11-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and neck cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with cancers of the mid-pharynx, hypopharynx, or larynx undergoing radical treatment at the National Cancer Center Hospital East and participating institutions between the date of study approval and March 31, 2026 2) Patients diagnosed as resectable cT3 or higher by imaging tests (CT, MRI) or endoscopy 3) Patients whose tumor oxygen saturation can be measured by oxygen saturation imaging endoscopy 4) Patients who are at least 18 years of age at the time consent is obtained 5) Patients whose written consent has been obtained from the patient

Exclusion criteria

Exclusion criteria: Patients deemed inappropriate by the principal investigator

Design outcomes

Primary

Measure	Time frame
Association between tumor oxygen saturation and percentage of complete response	—

Secondary

Measure	Time frame
Association between tumor oxygen saturation and gene expression profiles Association between tumor oxygen saturation and protein expression profiles Association between tumor oxygen saturation and local progression-free survival Tumor oxygen saturation in relation to overall survival Tumor oxygen saturation in relation to progression-free survival Association between tumor oxygen saturation and sensitivity	—

Measure

Time frame

Association between tumor oxygen saturation and gene expression profiles Association between tumor oxygen saturation and protein expression profiles Association between tumor oxygen saturation and local progression-free survival Tumor oxygen saturation in relation to overall survival Tumor oxygen saturation in relation to progression-free survival Association between tumor oxygen saturation and sensitivity

—

Countries

Japan

Contacts

Public ContactWataru Okano

National Cancer Center Hospital East Department of Head and Neck Surgery

wokano@east.ncc.go.jp04-7133-1111

Outcome results