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Evaluation of the Effect of Donepezil on Rocuronium-induced Neuromuscular Blockade: A Single-Center Prospective Observational Study

Evaluation of the Effect of Donepezil on Rocuronium-induced Neuromuscular Blockade: A Single-Center Prospective Observational Study - Evaluation of the Effect of Donepezil on Rocuronium-induced Neuromuscular Blockade

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000057634
Enrollment
80
Registered
2025-04-17
Start date
2025-04-17
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General anesthesia with neuromuscular blockade

Interventions

None listed

Sponsors

Hamamatsu University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients undergoing general anesthesia Aged 75 years or older Obtained informed consent

Exclusion criteria

Exclusion criteria: Patients taking cholinesterase inhibitors other than donepezil History of allergy to general anesthetic agents Severe obesity or cachexia Presence of a pacemaker or implantable cardioverter-defibrillator (ICD) Presence of prosthetic devices in the upper limbs Inappropriate indication for the use of neuromuscular blocking agents Inappropriate for intravenous anesthetic induction Presence of organ dysfunction Emergency surgery Deemed ineligible by the investigators

Design outcomes

Primary

MeasureTime frame
Time from Rocuronium Administration to Onset of Complete Neuromuscular Blockade Time Required for Recovery from Neuromuscular Blockade

Secondary

MeasureTime frame
The association between differences in patient populations and variations in general anesthesia management, including the types and dosages of anesthetic agents, concomitant medications, and vital signs.

Countries

Japan

Contacts

Public ContactYuji Suzuki

Hamamatsu University School of Medicine Department of Anesthesiology and Intensive Care Medicine

suzukiy@hama-med.ac.jp0534352738

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026