Liver cirrhosis with ascites
Conditions
Interventions
Patients with liver cirrhosis and ascites will undergo lymphangiography once during hospitalization. A total of 10 mL of Lipiodol will be injected into the right inguinal lymph node. After completion
Sponsors
Ehime University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 20 years or older with liver cirrhosis who have a history of hepatic ascites and currently have persistent ascites. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. No restrictions regarding sex.
Exclusion criteria
Exclusion criteria: Patients who are unable to remain at rest during the procedure. Patients with contraindications to iodinated contrast agents. Patients with comorbid conditions other than liver disease that may cause systemic edema, such as heart failure with BNP >= 100 pg/mL or renal disease with proteinuria (>= 3+) or estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2. Pregnant women or patients who may be pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study is to clarify the relationship between lymphatic drainage function and the severity of hepatic ascites. Patients will be stratified into two groups based on their response to diuretics: a non-refractory ascites group (ascites improved with diuretics) and a refractory ascites group (ascites not improved despite diuretic treatment). The contrast agent inflow velocity was compared between the groups. | — |
Countries
Japan
Contacts
Public ContactMasashi Hirooka
Ehime University of Medicine Department of Gastroenterology and Metabology
Outcome results
None listed