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Research on Mastication and Cognitive Function

Effects of Gum Chewing Training on Cognitive Function - Effects of Gum Chewing on Cognitive Function

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000057437
Enrollment
84
Registered
2025-04-01
Start date
2025-05-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy older adults

Interventions

chewing training with gum (3 times a day) and participation in lectures (once a month) participation in lectures (once a month)

Sponsors

Tokyo Metropolitan Institute for Geriatrics and Gerontology
Lead Sponsor
LOTTE CO.,Ltd., Meiji University
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Those who understand the purpose of this study and can consent to it. 2. Those who had masticatory function of 3 or higher (assessed by chewing gum). 3. Those who have at least 20 functional teeth. 4. Those who scored 24 or above on the MMSE-J

Exclusion criteria

Exclusion criteria: 1. Those who have incomplete data 2. Those who have cerebrovascular disorder (including pre-existing) 3. Those who have been diagnosed with dementia 4. Those who have been diagnosed with depression 5. Those who cannot chew or eat gum 6. Those who use a cardiac pacemaker 7. Those who are contraindicated for MRI examinations due to the use of defi brillators, magnetic metal implants, etc. 8. Those who are participating in other intervention studies, or will be participating in such studies within 4 weeks 9. Those who are judged to be ineligible for the study by the dentists (principal investigators or research coordinators)

Design outcomes

Primary

MeasureTime frame
cognitive function

Secondary

MeasureTime frame
oral function, cognitive function, brain volume, resting state functional connectivity

Countries

Japan

Contacts

Public ContactMaki Shirobe

Tokyo Metropolitan Institute for Geriatrics and Gerontology Research Team for Promoting Independence and Mental Health

mshirobe@tmig.or.jp03-3964-1141

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026