Exploring the Link Between Immune Imbalance and IL-27 in Asthma

Analysis of IL-27 - mediated Regulatory Activity in Tr1 cells of Patients in mild asthma - Analysis of IL-27 regulation of Tr1 cells in asthma

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000057424

Enrollment

Registered

2025-04-01

Start date

2025-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic mild asthma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Atopic mild asthmatics and non-atopic non asthmatics 2. Never smokers

Exclusion criteria

Exclusion criteria: 1. Unable to undergo pulmonary function tests 2. Pregnant, possibly pregnant, or nursing 3. Participants who judged that the research directors and researchers were inappropriate

Design outcomes

Primary

Measure	Time frame
The primary endpoint is to investigate the regulatory activity of IL-27 in Tr1 cells by evaluating the frequency of IL-27 receptor expression and phosphorylated STAT1/STAT3.	—

Secondary

Measure	Time frame
The secondary endpoint is to investigate the correlation between the regulatory activity of IL-27 in Tr1 and the following items (airway hyperresponsiveness, peripheral blood eosinophils, FENO, lung function).	—

Countries

Japan

Contacts

Public ContactMasanobu Matsuoka

Kurume University Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University Schoo

matsuoka_masanobu@kurume-u.ac.jp0942-31-7560

Outcome results