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Molecular Profiling and Biomarker analysis in Resectable Non-small Lung Cancer for Precision Perioperative Therapy

Molecular Profiling and Biomarker analysis in Resectable Non-small Lung Cancer for Precision Perioperative Therapy - MERCURY

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000057406
Enrollment
350
Registered
2025-03-26
Start date
2025-05-26
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-small cell lung cancer

Interventions

None listed

Sponsors

National Cancer Center Hospital East
Lead Sponsor
iTMS Co., Ltd.
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) Age 18 years or older at the time of obtaining consent 2) Participants with resectable clinical stage I -III non-small cell lung cancer 3) The following treatments are planned at the participating institutions: Cohort A : Neoadjuvant treatment cohort Cohort B: Up-front surgery Cohort 4) ECOG Performance Status of 0 or 1 5) Written informed consent has been obtained from the participant for participation in this study.

Exclusion criteria

Exclusion criteria: 1)Presence of active co-occurring malignancies 2) Pregnant 3) Have undergone hematopoietic stem cell transplantation 4) Any other cases deemed unsuitable for inclusion in this study by the principal investigator or sub-investigator.

Design outcomes

Primary

MeasureTime frame
Correlation of molecular profiles, including genetic abnormalities, RNA expression, immune cell phenotypes, and minimal residual disease (MRD) in peripheral blood and tumor tissue with recurrence and prognosis.

Secondary

MeasureTime frame
Relationships among molecular profiles, treatment outcomes, clinical-pathological factors such as treatment course, imaging findings, and pathological observations.

Countries

Japan

Contacts

Public ContactKotaro Nomura

National Cancer Center Hospital East Department of Thoracic Surgery

kotnomur@east.ncc.go.jp04-7133-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026