healthy volunteers
Conditions
Interventions
None listed
Sponsors
Division of Dental Anesthesiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: after informed consent is obtained, over 18 years old
Exclusion criteria
Exclusion criteria: The inability to give informed consent, under 18 years old Individuals who have no history of taking acetaminophen and loxoprofen sodium. Individuals who are contraindicated for acetaminophen and loxoprofen sodium - peptic ulcer,serious blood abnormalities,severe liver disorder,severe renal impairment,severe cardiac dysfunction,a history of hypersensitivity to the ingredients of acetaminophen and loxoprofen sodium, aspirin asthma ,women in the late stages of pregnancy. A history of hypersensitivity to the ingredients of lactose hydrate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The evaluation of CPM effect before and after taking acetaminophen. CPM effect is evaluated by pressure pain threshold (PPT) before and during conditioning stimulus. | — |
Secondary
| Measure | Time frame |
|---|---|
| the modulation of QST (the Thermal Pain Illusion(TPI), Temporal Summation(TS), Offset Analgesia(OA) etc) and the effect of background (for example, psychology test including SDS, STAI, PCS etc), and the stress evaluated by catecholamine concentrations in plasma, urine and sweat. As a control, the effect of lactose monohydrate or loxoprofen sodium will be measured on separate days. | — |
Countries
Japan
Contacts
Public ContactYuka Oono
Department of Diagnostic and Therapeutic Sciences, School of Dentistry, Meikai University Division of Dental Anesthesiology
Outcome results
None listed