Respiratory disorders, including respiratory failure
Conditions
Interventions
Respiratory management with Nasal High Flow (flow rate changed from 0 L/min to 60 L/min, then decreased to 30 L/min, and finally returned to 0 L/min).
Respiratory management with Nasal High Flow (flow
Sponsors
Kanagawa Dental University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy adult volunteers 20 years of age or older who understand the purpose of this study and agree to participate in the research.
Exclusion criteria
Exclusion criteria: 1. under 20 years of age. 2. general status classification (ASA-PS classification) of the American Society of Anesthesiologists is 3 or higher. 3. who have nasal obstruction and difficulty breathing through the nose on a daily basis (including those who experience epistaxis easily). 4. those with psychiatric disorders or those taking psychotropic drugs. 5. patients who may not be able to measure EEG or BIS values properly (including those with brain lesions). 6. patients who have expressed (including verbally) their refusal to participate in this study. 7. other patients who are judged by the principal investigator to be inappropriate to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective comfort level (VAS) for respiratory management methods | — |
Secondary
| Measure | Time frame |
|---|---|
| (i) Salivary stress markers (amylase concentration, salivary cortisol concentration, salivary sIgA concentration, salivary sIgG concentration) (ii) Blood pressure (systolic, diastolic, average), pulse rate, SpO2, BIS value, sedation score (iii) Heart rate variability by ECG RR interval (iv) Tissue oxygenation index, tissue hemoglobin index, oxygenated hemoglobin change, deoxygenated hemoglobin change, total hemoglobin change by NIRS | — |
Countries
Japan
Contacts
Public ContactAtsuki Yamaguchi
Kanagawa Dental University Department of Dental Anesthesiology
Outcome results
None listed