Food allergy
Conditions
Interventions
Fixed low-dose antigen intake. Ingest antigen every day according to the protocol.
Elimination diet
Sponsors
Aichi Children's Health and Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children with severe food allergies, such as tree nut or peanut allergies, who are capable of possessing and managing an epinephrine auto-injector.
Exclusion criteria
Exclusion criteria: Patients with severe comorbidity Patients with uncontrollable asthma or atopic dermatitis Patients whose parents can not manage adrenalin autoinjector Patients who required epinephrine (excluding inhalation) during the entry oral food challenge or who ended with only mild subjective symptoms. Patients deemed unsuitable by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with a negative oral food challenge results six months after starting intake (or elimination) | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety and continuity of antigen intake The threshold dose of antigen and severity of allergic reaction provoked in OFCs. The shift of laboratory data (e.g. specific IgE titer) | — |
Countries
Japan
Contacts
Public ContactKatsumasa Kitamura
Aichi Children's Health and Medical Center Allergy and Immunology Center, Department of Allergy
Outcome results
None listed