chronic pain
Conditions
Interventions
None listed
Sponsors
Kawasaki Medical School
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Nociceptive Pain Group 1 (HO Group) Individuals scheduled to undergo total hip arthroplasty (THA) due to hip osteoarthritis. Individuals who understand the purpose and details of this study and provide written informed consent voluntarily. Nociceptive Pain Group 2 (FF Group) Patients undergoing surgery for femoral fracture. Individuals who understand the purpose and details of this study and provide written informed consent voluntarily. Nociplastic Pain Group (CPP Group) Patients with chronic primary pain (pain with no identifiable physical cause). Individuals who understand the purpose and details of this study and provide written informed consent voluntarily. Neuropathic Pain Group (RT/Shingles Group) Patients undergoing radiotherapy for cancer-related neuropathic pain or patients with postherpetic neuralgia Individuals who understand the purpose and details of this study and provide written informed consent voluntarily. Control Group Individuals without persistent bodily pain for more than three months. Individuals who understand the purpose and details of this study and provide written informed consent voluntarily.
Exclusion criteria
Exclusion criteria: (HO Group) Individuals with severe pain in areas other than the hip joint (bilateral hip osteoarthritis is not excluded). Individuals with severe cognitive impairment (delirium, dementia, intellectual disability, or other mental function decline) at the time of pre-intervention assessment. Individuals with significant difficulty in communication, reading, or writing in Japanese. Individuals deemed unsuitable for participation by the principal investigator. (FF Group) Individuals with severe pre-existing hip osteoarthritis. Individuals with severe cognitive impairment (delirium, dementia, intellectual disability, or other mental function decline) at the time of pre-intervention assessment. Individuals with significant difficulty in communication, reading, or writing in Japanese. Individuals deemed unsuitable for participation by the principal investigator. (CPP Group) Individuals with conditions requiring urgent medical treatment. Individuals with a history or current diagnosis of alcohol or drug abuse. Individuals with a history or current diagnosis of mania or psychosis. Individuals with significant suicidal ideation. Individuals with severe cognitive impairment. Individuals with significant difficulty in communication, reading, or writing in Japanese. Individuals deemed unsuitable for participation by the principal investigator. (RT Group) Individuals experiencing severe pain unrelated to cancer or postherpetic neuralgia. Individuals with severe cognitive impairment (delirium, dementia, intellectual disability, or other mental function decline) at the time of pre-intervention assessment. Individuals with significant difficulty in communication, reading, or writing in Japanese. Individuals deemed unsuitable for participation by the principal investigator. Control Group Identical to the CPP group, with the seventh criterion being the inclusion of individuals exhibiting any deviation in the QOL questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Classification of pain using circulating miRNAs (nociceptive pain, nociplastic pain, and neuropathic pain | — |
Secondary
| Measure | Time frame |
|---|---|
| Variations in miRNA Expression Levels and Their Association with QOL Indicators (EQ-5D, NRS, PCS, PDAS, TSK-11) | — |
Countries
Japan
Contacts
Public Contacthiroyuki nishie
kawasaki Medical School Department of Advanced Oncoloby
Outcome results
None listed