The Effect of Adding Transcutaneous Electrical Nerve Stimulation (TENS) to Static Bicycle Intervention on Inflammatory Cytokine Levels (IL-6), Range of Motion (ROM), and Functional Ability in Patients with Knee Osteoarthritis

The Effect of Adding Transcutaneous Electrical Nerve Stimulation (TENS) to Static Bicycle Intervention on Inflammatory Cytokine Levels (IL-6), Range of Motion (ROM), and Functional Ability in Patients with Knee Osteoarthritis - BEST-KOA

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000057273

Enrollment

Registered

2025-03-12

Start date

2025-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

this study aims to investigate the effect of adding TENS to static bicycle exercise in KOA patients. The study will evaluate the impact on inflammatory cytokine IL-6 levels, range of motion (ROM), and functional ability.

Interventions

Static Bicycle Static Bicycle and TENS

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diagnosed with grade II-III KOA Aged 45-74 years Completed 8 intervention sessions

Exclusion criteria

Exclusion criteria: - Received other treatments outside the study protocol - Comorbidities like cardiopulmonary disease, neurological disorders, or post-knee surgery - Pacemaker users - Active joint infections

Design outcomes

Primary

Measure	Time frame
IL-6 Levels: Measured using ELISA from venous blood samples. Range of Motion (ROM): Measured using a goniometer in degrees. Flexion: 135, Extension: 0. Functional Ability: Assessed using the WOMAC Index (higher scores indicate worse function).	—

Countries

Asia(except Japan)

Contacts

Public Contactyulisar asfia rasak

biomedical science biomedical science

ulliasfia24@gmail.com085159939922

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026