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The Effect of Adding Neuromuscular Electrical Stimulation (NMES) in Static Bicycle Intervention on Inflammatory Cytokine Levels (IL-6), Range Of Motion (ROM) and Functional Ability in Knee Osteoarthritis Patients.

The Effect of Adding Neuromuscular Electrical Stimulation (NMES) in Static Bicycle Intervention in Knee Osteoarthritis Patients - The Effect of NMES to SB in OA Knee Patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000057258
Enrollment
32
Registered
2025-03-11
Start date
2024-12-31
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Static Bicycle Static Bicycle and Neuromuscular Electrical Stimulation (NMES)

Sponsors

self funding
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: had been diagnosed with grade 2-3 OA knee dextra or sinistra based on the Kellgren and Lawrence classification through radiological examination (x-ray) and diagnosis by an orthopedic doctor. Recruitment of research samples was based on inclusion criteria, including 45-74 years old, both men and women, experiencing functional limitations, knee range of motion (ROM) and quadriceps muscle weakness in the extremities experiencing knee OA

Exclusion criteria

Exclusion criteria: Exclusion criteria included having a history of other diseases such as cardiorespiratory disease, neurological and other knee joint disorders other than knee osteoarthritis, receiving intra-articular injections within the previous three months or surgery, using pacemakers or internal metal materials, having infections or other inflammatory conditions and having contractures in the muscles around the knee joint.

Design outcomes

Primary

MeasureTime frame
reduce interleukin 6 (IL-6) cytokine levels, improve functional ability and knee joint flexion ROM after 4 weeks of intervention in each treatment group

Secondary

MeasureTime frame
there was a significant difference between the study groups in improving functional ability and ROM flexion of the knee joint. however, the decrease in IL-6 levels only occurred in the static bicycle intervention group added with NMES.

Countries

Asia(except Japan)

Contacts

Public ContactWardatun Wahdaniyah Rasidi

Hasanuddin University Biomedical Science Study Program

wardatunwahdaniyah16@gmail.com+6285145205857

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026