Effects of activation of TRPM8 in human skin on thermal sensation and circulatory responses related with cold acclimation

Effects of activation of TRPM8 in human skin on thermal sensation and circulatory responses related with cold acclimation - Effects of activation of TRPM8 on thermoregulatory responses

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056954

Enrollment

Registered

2025-03-01

Start date

2025-02-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

Immersion of forearm in cold water (20C) 10% menthol application 10% menthol application and immersion of forearms in cold water (20C)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: No respiratory disease, no regular medication, no smoking history, not a water-based activity participant

Exclusion criteria

Exclusion criteria: Respiratory diseases, those with a history of taking daily medication or smoking, and those who engage in water-based activities

Design outcomes

Primary

Measure	Time frame
Heart rate, arterial blood pressure, skin blood flow, thermal sensation, thermal comfort	—

Countries

Japan

Contacts

Public ContactTomomi Fujimoto

Niigata University of Health and Welfare Department of Health and Sports

fujimoto@nuhw.ac.jp0252574675

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026