Patients with liver cirrhosis complicated by covert encephalopathy
Conditions
Interventions
For 6 months,Rifaximin is orally administered after each meal in 3 divided doses of 1200mg per day
Sponsors
Bellland General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients below age-specific cut-off values on the Stroop-test 2. Patients between 20 and 80 years of age, any gender 3. Patients who understand the contents of the consent document and are able to sign the consent form freely and voluntarily
Exclusion criteria
Exclusion criteria: 1. Patients under 19 years old and over 80 years old 2. cancer-bearing patient 3. Pregnant and lactating patients 4. Patients with poorly controlled ascites 5. Patients with a history of overt hepatic encephalopathy 6. Patients with severely impaired renal function (eGFR<30 ml/min/1.73m2) 7. Patients with confirmed refusal to participate 8. Patients showing signs of alcohol dependence 9. Dementia (PS2 or higher) 10. Patients with psychosis who are regularly attending or hospitalized in a neuropsychiatric department and who are considered to be difficult to participate in the study 11. Other patients deemed ineligible by the investigators and subinvestigators 12. Patients with other addictions 13. Patients with intellectual disabilities 14. Patients with cerebral organic mental disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All scores on the Chronic Liver Disease Questionnaire | — |
Countries
Japan
Contacts
Public ContactYosuke Aihara
Bellland General Hospital gastroenterology
Outcome results
None listed