Investigation of the Association Between Pericoronary Adipose Tissue Attenuation and the Temporal Changes in Plaque Characteristics Evaluated by Optical Coherence Tomography

Investigation of the Association Between Pericoronary Adipose Tissue Attenuation and the Temporal Changes in Plaque Characteristics Evaluated by Optical Coherence Tomography - Investigation of the Association Between Pericoronary Adipose Tissue Attenuation and the Temporal Changes in Plaque Characteristics Evaluated by Optical Coherence Tomography

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056921

Enrollment

300

Registered

2025-05-10

Start date

2016-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient Criteria Patients who underwent follow-up coronary angiography (CAG) and optical coherence tomography (OCT) at least 3 months and within 24 months after baseline CAG and OCT. Patients who underwent coronary computed tomography angiography (cCTA) within 5 months prior to baseline CAG and OCT. Patients aged 20 years or older at the time of baseline CAG and OCT. Lesion Criteria Lesions with plaque showing a luminal area stenosis between 30% and 70% on baseline OCT evaluation.

Exclusion criteria

Exclusion criteria: Patients with stent placement in the proximal right coronary artery (<10 mm) or the left main coronary artery. Patients with a history of coronary artery bypass grafting (CABG). Patients for whom cCTA analysis is not feasible. Patients for whom OCT analysis is not feasible. Lesion Criteria Lesions treated with percutaneous coronary intervention (PCI) at the time of baseline CAG and OCT (including within 5 mm of the treated segment).

Design outcomes

Primary

Measure	Time frame
Based on previous reports, patients are classified into two groups: the High PCAT attenuation group, defined as having a PCAT attenuation of -75 HU or higher, and the Low PCAT attenuation group, defined as having a PCAT attenuation of less than -75 HU. The change in fibrous cap thickness of the target lesion observed by OCT is compared between these two groups.	—

Countries

Japan

Contacts

Public ContactKeisuke Iida

Kobe University Hospital Department of Cardiovascular Medicine, Division of Internal Medicine, Graduate School of Medicine

wanhira@gmail.com078-382-5846

Outcome results