Adult
Conditions
Interventions
Only one side of the face, apply test cosmetics for 12 weeks.
The other side of the face, do not apply test cosmetics for 12 weeks.
Sponsors
Yamada Bee Company, Inc.
Research Center for Immunological Analysis, Inc.
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Subjects who feel skin aging (wrinkle, elasticity, sagging). 2) A healthy Japanese females aged 50-80 at the time of consent. 3) Subjects can understand and comply with the rules written in protocol during clinical study period. 4) Subjects whose written informed consent has been obtained.
Exclusion criteria
Exclusion criteria: 1) Subjects using cosmetics that contain the ingredient involved in this study. 2) Subjects at risk for allergy to the test cosmetics. 3) Subjects with cosmetic allergies. 4) Subjects attending or planning to attend dermatology clinics (for treatment of atopic dermatitis, etc.). 5) Subjects with scraped or inflamed skin on the measuring area. 6) Subjects receiving hormone replacement therapy (estrogen, progesterone preparations (oral, paste, ointment, etc.)). 7) Subjects who have got cosmetic medical treatment (hyaluronic acid injections, etc.) which would affect the measuring area within 1 year. 8) Subjects who cannot avoid sunburn during the test period. 9) Subjects who cannot be prohibited from receiving beauty care (facial esthetics, epilation, etc.). 10) Subjects who cannot maintain regular lifestyle. 11) Subjects who have an irregular habit because of working at night or working under work-shift form. 12) Subjects who drink more than 500 mL beer daily. 13) Subjects who have been smoking (including electronic cigarettes) for 3 months prior to obtaining consent. 14) Subjects who participated in other clinical trial within last 1 month. 15) Subjects working at the health food, cosmetics or pharmaceutical company. 16) Subjects using cosmetic, quasi-drugs, healthy foods that may affect the test. 17) Subjects deemed inappropriate to participate in this study by the principle investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin elasticity | — |
Secondary
| Measure | Time frame |
|---|---|
| Water content of stratum corneum Transepidermal water loss Skin glossiness Skin color Skin thickness VISIA image analysis Pore structure Smart Skin Care's score Sagging skin Skin questionnaire | — |
Countries
Japan
Contacts
Public ContactChizuru Fujikura
Yamada Bee Company, Inc. Yamada Bee Company group Institute for Beauty Science, R&D department
Outcome results
None listed