Piperacillin-tazobactam for antimicrobial prophylaxis during pancreatoduodenectomy: prospective observational study

Piperacillin-tazobactam for antimicrobial prophylaxis during pancreatoduodenectomy: prospective observational study - Piperacillin-tazobactam for antimicrobial prophylaxis during pancreatoduodenectomy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056774

Enrollment

200

Registered

2025-01-21

Start date

2025-01-16

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases requiring pancreatoduodenectomy (e.g., pancreatic cancer, bile duct cancer)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients for whom pancreatoduodenectomy is being planned 2. Patients must be 18 years of age or older at the time of enrollment

Exclusion criteria

Exclusion criteria: 1. Inability to receive trial antibiotics due to allergy or medical issues 2. Active infection

Design outcomes

Primary

Measure	Time frame
Development of postoperative SSI within 30 days.	—

Secondary

Measure	Time frame
30-day mortality, sepsis, septic shock, percutaneous drain placement, pneumonia, postoperative reintubation, prolonged ventilation, venous thromboembolism events, kidney failure, urinary tract infections, stroke, myocardial infarction, cardiac arrest, Clostridioides difficile colitis, hospital readmission, reoperation, and length of hospital stay, postoperative delayed gastric emptying, and pancreatic fistula grade B and grade C defined by International Study Group of Postoperative Pancreatic Fistula.	—

Measure

Time frame

30-day mortality, sepsis, septic shock, percutaneous drain placement, pneumonia, postoperative reintubation, prolonged ventilation, venous thromboembolism events, kidney failure, urinary tract infections, stroke, myocardial infarction, cardiac arrest, Clostridioides difficile colitis, hospital readmission, reoperation, and length of hospital stay, postoperative delayed gastric emptying, and pancreatic fistula grade B and grade C defined by International Study Group of Postoperative Pancreatic Fistula.

—

Countries

Japan

Contacts

Public ContactKenta Baba

Hiroshima University Hospital Gastrointestinal Surgery

bbkenta@hiroshima-u.ac.jp082-257-5216

Outcome results