Temporal changes and outcome prediction of blood renin levels in patients with hypotension

Kinetics and prognostic performance of serum renin concentration in critically ill hypotensive patients: a multicenter prospective cohort study - RICH study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056581

Enrollment

400

Registered

2025-01-10

Start date

2025-07-17

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Shock

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients meeting all of the following criteria will be included. 1. Admitted to the ICU within 24 hours 2. Aged 18 years or older 3. Requiring a continuous infusion of vasopressors (i.e., norepinephrine, vasopressin, epinephrine, phenylephrine, dopamine) to maintain the target blood pressure 4. Expected to stay in the ICU longer than 24 hours

Exclusion criteria

Exclusion criteria: Patients meeting either of the following criteria will be excluded. 1. History of primary or secondary aldosteronism 2. Active palliation 3. Pregnancy or lactation 4. Absence of informed consent from the study participant or their next of kin 5. Judgment of the treating physician

Design outcomes

Primary

Measure	Time frame
30-day mortality	—

Secondary

Measure	Time frame
1. ICU mortality 2. Major Adverse Kidney Events at day 30 (MAKE30) 3. Dependence on renal replacement therapy at day 30 4. Persistent renal dysfunction at day 30 5. Severe acute kidney injury at day 7 6. Days of alive and free from intravenous vasopressor therapy at day 30	—

Countries

Japan

Contacts

Public ContactYuki Kotani

Kameda Medical Center Department of Intensive Care Medicine

kotani.yuki@kameda.jp04-7092-2211

Outcome results