A multicenter retrospective study on the frequency of recurrence and risk factors for recurrence following surgical resection of pancreatic neuroendocrine tumors.

A multicenter retrospective study on the frequency of recurrence and risk factors for recurrence following surgical resection of pancreatic neuroendocrine tumors. - A retrospective study on the frequency and risk factors of recurrence following surgical resection of pancreatic neuroendocrine tumors.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056506

Enrollment

800

Registered

2024-12-20

Start date

2024-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The surgically resected pancreatic neuroendocrine tumor

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who meet all of the following criteria at the time of registration are included: 1. Patients who underwent pancreatic resection between January 1996 and December 2019 and were pathologically diagnosed with pancreatic neuroendocrine tumors (including NEC G3 and MiNEN), regardless of the surgical procedure. 2. Immunohistochemical staining for Ki67 was performed on resected specimens, and the Ki67 labeling index is available. 3. Malignancy grading based on the WHO 2019 classification (NET G1, G2, G3, NEC G3, MiNEN) is feasible.

Exclusion criteria

Exclusion criteria: 1. Surgical resection of recurrence lesions only (e.g., liver metastases, lymph nodes). 2. Surgical resection of metastatic lesions solely for the purpose of mass reduction or alleviation of hormone-producing symptoms. 3. Cases in which differentiation from conventional pancreatic cancer is challenging in pathological diagnosis. 4. Other cases deemed unsuitable for inclusion in this study by the principal investigator or co-investigators.

Design outcomes

Primary

Measure	Time frame
Identification of risk factors for recurrence in all surgically resected pancreatic neuroendocrine tumors.	—

Countries

Japan

Contacts

Public ContactYasuhiro Komori

National Cancer Center Hospital Department of Hepatobiliary and Pancreatic Oncology

yakomor@ncc.go.jp03-3542-2511

Outcome results