Acute pancreatitis
Conditions
Interventions
Target doses of protein should be at least 1.2 g/kg on Day 4 and 1.8 g/kg on Days 10-14.
Target doses of protein are less than 0.6 g/kg on Day 4 and less than 0.9 g/kg on Days 10-14.
Sponsors
Keio University School of Medicine Division of Gastroenterology and Hepatology, Department of Internal Medicine Eisuke Iwasaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of pancreatitis: Persistent abdominal pain associated with pancreatitis. Blood lipase (upper limit of normal: 53 IU/L) or amylase (upper limit of normal: 121 IU/L) is elevated more than 3 times the upper limit of normal; CT, MRI, or ultrasound shows abnormal findings associated with pancreatitis. Patients who meet two of the three criteria (including acute exacerbation of chronic pancreatitis) 2. Patients who require admission to a critical care unit (ICU, HCU, emergency, critical care center, etc.) or,have BISAP 3 or higher. 3. SOFA less than 10 points
Exclusion criteria
Exclusion criteria: 1) Patients who are deemed by their physician to be ineligible for nutritional therapy 2) Patients who are deemed unsuitable for this study by their physician (e.g., history of self-discharge) 3) Patients who are not expected to survive longer than one week by the physician 4) Patients who are judged by the physician to be inadequate for adequate protein administration (e.g., concurrent fulminant hepatitis) 5) Patients who do not consent to the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified pancreatitis activity scoring system (PASS) (Day14) | — |
Secondary
| Measure | Time frame |
|---|---|
| modified PASS (Day 4, 7, 10), PASS (Day 4, 7, 10, 14), mortality (at discharge, 1 year), SOFA (Day 14), Barthel Index (Day 28) EQ-5D-5L (Day 28) CRP (Day 14), Alb (Day 14), lymphocyte count (Day 14), phosphorus (Day 14), prealbumin (Day 14), skeletal muscle index at the level of the third lumbar spine by CT (Day 14) mortality due to pancreatitis during hospitalization, severe acute pancreatitis based on the revised Atlanta classification, infected pancreatic necrosis, WON, drainage or necrosectomy for infected pancreatic necrosis, survival discharge days, cost, time from diagnosis to cure of pancreatitis, days in intensive care unit etc, number of days to start oral intake, use and duration of ventilator use, use and duration of dialysis use, use and duration of cardioactive drugs use, new diabetes and insulin use, candida infection, invasive procedure, adverse events (through Day 14) | — |
Countries
Japan
Contacts
Public ContactMasayasu Horibe
Keio University School of Medicine Division of Gastroenterology and Hepatology, Department of Internal Medicine
Outcome results
None listed