A clinical study evaluating the whitening efficacy and tooth hypersensitivity of newly develop at-home whitening system

Whitening efficacy and tooth sensitivity of at-home whitening with 6% hydrogen peroxide: A randomized controlled clinical trial - Clinical study on at-home whitening with 6% hydrogen peroxide

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056501

Enrollment

Registered

2025-03-31

Start date

2024-07-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vital discolored teeth

Interventions

at-home whitening with 6% hydrogen peroxide, 10 days, 1h at-home whitening with 10% carbamide peroxide, 14 days, 2 h

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The inclusion criteria for this study were the possession of six vital front teeth, first premolars, and second premolars in the upper jaw without caries lesions, restorations, large cracks, or tooth sensitivity. In addition, the patients had to be at least 18 years old with a maxillary anterior shade between A2 and A3.5 (VITA classical A1-D4 shade guide).

Exclusion criteria

Exclusion criteria: The exclusion criteria were allergy to hydrogen peroxide, periodontal disease, poor oral hygiene, ongoing treatment for a serious, systemic, and chronic disease, pregnancy or breastfeeding, previous whitening treatment, severe tetracycline-induced discoloration or fluorosis, and any other conditions deemed unsuitable by the supervising dentist.

Design outcomes

Primary

Measure	Time frame
whitening efficacy (after 24 H), occurrence of hypersensitivity (during treatment, after 24 h),	—

Secondary

Measure	Time frame
color stability (6-month, 1-year, 2-year)	—

Countries

Japan

Contacts

Public ContactToshiki Takamizawa

Nihon University School of Dentistry Department of Operative Dentistry

takamizawa.toshiki@nihon-u.ac.jp0332198141

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026