dementia
Conditions
Interventions
Once a day (can be divided into up to three times), orally ingest 25 g of chocolate containing cacao flavanols per day.
Once a day (can be divided into up to three times), orally ingest 25 g of chocol
Sponsors
Kobe University Graduate School of Health Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Participants who have used a center-based cognicare program for at least 3 months, and who are aged between 60 and 85 years old Written consent must be obtained
Exclusion criteria
Exclusion criteria: People with dementia or mild cognitive impairment (MMSE score of less than 26) People who have been assessed as requiring long-term care level 1 or above People who have been assessed as having severe liver or kidney dysfunction People with a history of allergy to cacao People who consume chocolate or cocoa on a daily basis People who the researchers have judged to be unsuitable for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in composite score for cognitive function in cognitive function assessment at initial evaluation and 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Presence or absence of changes in blood data from the initial evaluation to the 3-, 6-, and 12-month follow-up evaluations (confirmation of safety) 2) Change in each cognitive function test from the initial assessment to the 6- and 12-month follow-up assessments 3) Change in motor function assessment from the initial assessment to the 6- and 12-month follow-up assessments 4) Presence or absence of change in vascular function from the initial assessment to the 6- and 12-month follow-up assessments 5) Presence or absence of change in intestinal bacterial flora from the initial assessment to the 6- and 12-month follow-up assessments | — |
Countries
Japan
Contacts
Public ContactHisatomo Kowa
Kobe University Graduate School of Health Sciences Dementia Preventing Center
Outcome results
None listed