The impact of pentosidine on instrumentation failure after lumbar interbody fusion surgery

A prospective cohort study on the impact of pentosidine on instrumentation failure after lumbar interbody fusion surgery - A prospective cohort study on the impact of pentosidine on instrumentation failure

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056487

Enrollment

200

Registered

2024-12-18

Start date

2024-12-18

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar degenerative diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients undergoing posterior lumbar interbody fusion (PLIF/TLIF) for degenerative conditions such as lumbar degenerative spondylolisthesis, lumbar isthmic spondylolisthesis, lumbar spondylolysis, or lumbar foraminal stenosis. 2.Patients aged 55 years or older at the time of surgery. 3.Patients who have received sufficient explanation about this study, fully understood the details, and provided voluntary consent either personally or through a representative.

Exclusion criteria

Exclusion criteria: 1.Patients undergoing surgery for pyogenic spondylitis or tuberculous spondylitis. 2.Patients undergoing surgery for metastatic bone tumors. 3.Patients undergoing surgery for spinal trauma or spinal cord injury. 4.Patients undergoing hemodialysis. 5.Patients with a history of lumbar fusion surgery. 6.Patients deemed unsuitable for inclusion in the study by the principal investigator.

Design outcomes

Primary

Measure	Time frame
The occurrence of pedicle screw loosening, cage subsidence, and cage retropulsion up to 24 months postoperatively.	—

Countries

Japan

Contacts

Public ContactYukitoshi Shimamura

Hakodate Central General Hospital Spine Center

shimamuy82055@gmail.com0138-52-1231

Outcome results