Develpoment of xerostomia treatment targeting minor salivary glands -Occlusal stimulation and minor gland sarivary secretion-

Develpoment of xerostomia treatment targeting minor salivary glands -Occlusal stimulation and minor gland sarivary secretion- - Occlusal stimulation and minor gland sarivary secretion

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056469

Enrollment

Registered

2024-12-16

Start date

2024-12-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Xerostomia

Interventions

Bite the splint disk with a thickness of about 1mm with upper and lower teeth. Dental local infiltration anesthesia into the gingiva (Oral injection dental cartridge)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults with lower and upper second incisor, canine, first premolar, second premolar, and first molar

Exclusion criteria

Exclusion criteria: Adults who are allergic to dental local anesthetics. Adults with hypertension, arteriosclerosis, heart failure, hyperthyroidism, and diabetes. Adults who are unable to make self-judgments due to dementia, etc. Adults who are pregnant, breastfeeding, or wish to become pregnant during the research period. Others who are judged be a dentist to be inappropriate for study participation.

Design outcomes

Primary

Measure	Time frame
Minor salivary glands secretion	—

Secondary

Measure	Time frame
Bite force, Whole salivary flow rate	—

Countries

Japan

Contacts

Public ContactMasahiro Iikubo

Tohoku University Division of Dental Informatic Radiology

masahiro.iikubo.c6@tohoku.ac.jp022-717-8930

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026