The association between radial wall strain and plaque rupture

The association between angiographically derived radial wall strain and the risk of plaque rupture - The association between radial wall strain and plaque rupture

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056462

Enrollment

Registered

2025-01-20

Start date

2025-01-20

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute coronary syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients whose OCT are available for assessment of plaque morphology Patients who had underwent index CAG Patients who had at least 1 de novo native coronary lesion Patients aged 20 years or older at index CAG Lesions with a percent diameter stenosis of 30% to 70% from quantitative coronary angiography (QCA) assessment Lesions with reference vessel diameter 2.0 mm or more by QCA assessment

Exclusion criteria

Exclusion criteria: Lesions of in-stent restenosis within 5 mm from stent edges Lesions with a left main coronary artery location Lesions with a distance of < 5 mm from the vessel ostium Lesions with previous coronary artery bypass grafting of the target vessel Lesions with difficulty in RWS analysis Lesions underwent revascularization, based on index CAG,before second-time CAG

Design outcomes

Primary

Measure	Time frame
RWS analized from index CAG in culprit lesions developing ACS with plaque rupture, and non-culprit lesions	—

Secondary

Measure	Time frame
RWS analysed from index CAG between plaque rupture, plaque erosion and calcified nodule, in culprit lesions Perioperative complication (distal embolization, slow flow/no reflow, intrastent plaque/thrombus protrusion and perioperative myocardial infarction) in PCI for culprit lesions. Major cardiac adverce events (target lesion revascularization, target vessel-related myocardial infarction and cardiac death) in culprit lesions. Major cardiac adverce events (non-culprit lesion related revascularization, non-culprit vessel-related myocardial infarction and cardiac death) in non-culprit lesions.	—

Measure

Time frame

RWS analysed from index CAG between plaque rupture, plaque erosion and calcified nodule, in culprit lesions Perioperative complication (distal embolization, slow flow/no reflow, intrastent plaque/thrombus protrusion and perioperative myocardial infarction) in PCI for culprit lesions. Major cardiac adverce events (target lesion revascularization, target vessel-related myocardial infarction and cardiac death) in culprit lesions. Major cardiac adverce events (non-culprit lesion related revascularization, non-culprit vessel-related myocardial infarction and cardiac death) in non-culprit lesions.

—

Countries

Japan

Contacts

Public ContactHiromasa Otake

Kobe University Graduate School of Medicine Division of Cardiovascular Medicine, Department of Internal Medicine

hotake@med.kobe-u.ac.jp078-382-5111

Outcome results