Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults

Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults - Sake lees and their impact on uremic toxins and gut health

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056444

Enrollment

Registered

2024-12-18

Start date

2022-01-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic constipation

Interventions

Intake 25g of sake lees or 50g of sake lees per day for 6 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Participants were eligible if they were aged 20 years or older and met the diagnostic criteria for chronic constipation.

Exclusion criteria

Exclusion criteria: Exclusion criteria included alcohol intolerance, antibiotic use within the previous 4 weeks, or use of medications causing diarrhea or constipation.

Design outcomes

Primary

Measure	Time frame
Changes in fecal uremic toxins (indole and cresol)	—

Secondary

Measure	Time frame
Changes in plasma D-alanine, constipation, and gut microbiome	—

Countries

Japan

Contacts

Public ContactToshiaki Tokumaru

Kanazawa University Hospital Department of Nutrition Management

tkmr-knz@staff.kanazawa-u.ac.jp0762652087

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026