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The Effect of Coffee-derived Mannooligosaccharides on Calcium Absorption in Healthy Adults -A Systematic Review with Meta-analysis-:Protocol

The Effect of Coffee-derived Mannooligosaccharides on Calcium Absorption in Healthy Adults -A Systematic Review with Meta-analysis-:Protocol - The Effect of Coffee-derived Mannooligosaccharides on Calcium Absorption in Healthy Adults -A Systematic Review with Meta-analysis-:Protocol

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000056403
Enrollment
Unknown
Registered
2025-10-01
Start date
2024-12-16
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The subjects are healthy volunteers (excluding those under 20, pregnant women, and lactating women, who were not suffering from any diseases). Studies that are relevant to the outcome in question and include participants being treated as patients will be excluded.

Interventions

None listed

Sponsors

Ajinomoto AGF, INC.
Lead Sponsor
Review team Mr. Katsuya Suzuki, Ajinomoto AGF, Inc. Dr. Shigeyoshi Fujii, Former employees of Ajinomoto AGF, Inc. Research Collaborator Professor Hiroharu Kamioka, Tokyo University of Agriculture Holders of library librarian qualifications
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: P-Participant:The subjects are healthy volunteers (excluding those under 20, pregnant women, and lactating women, who were not suffering from any diseases). Studies that are relevant to the outcome in question and include participants being treated as patients will be excluded. I-Intervention:The intervention condition is oral intake of a test product containing at least 0.5 g of 'coffee bean-derived mannooligosaccharides' (any form of intake). C-Comparison:A comparison was made among one receiving a placebo, another serving as a control group in which food was substituted with food that does not contain 'coffee-derived mannooligosaccharides' and group with no intervention. O-Outcome measurement: Primary outcomes:The primary outcome is the effect of promoting intestinal absorption of calcium.Specifically, the urinary calcium content (creatinine corrected) (mg/g Cr) at each hour of intake will be the primary endpoint. S-Study design:The research designs used in the literature were randomized parallel group controlled trials, quasi-randomized controlled trials, non-randomized controlled trials, and crossover studies. In addition, the languages of presentation were documents written in Japanese and English. In principle, the form of presentation should be an original paper, but short reports and reports may be accepted if the content can be identified. To avoid publication bias, studies that include results published in clinical trial registration databases are also eligible. For the time period, studies published from the first time the databases were opened or loaded to the date of the search will be included in the search.

Exclusion criteria

Exclusion criteria: Abstracts of conference presentations (conference proceedings) will be excluded they are considered insufficiently descriptive. Other gray documents will be excluded it is difficult to confirm their appropriateness.

Design outcomes

Primary

MeasureTime frame
The primary outcome is the effect of promoting intestinal absorption of calcium. Specifically, the urinary calcium content (creatinine corrected) (mg/g Cr) at each hour of intake will be the primary endpoint.

Countries

Japan

Contacts

Public ContactYuki Ishitani

Ajinomoto AGF, INC. Technology Development Dept. Technical Research and Development Institute

yuki.ishitani.4yu@agf.co.jp044-223-4157

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026