Adult
Conditions
Interventions
Foods containing high-dose propolis Daily intake: 566 mg Duration: 84 days
Foods containing low-dose propolis Daily intake: 566 mg Duration: 84 days
placebo food Daily intake: 566 mg Duration: 8
Sponsors
KYOWA TRIAL CO., LTD
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Healthy Japanese men and women aged more than 30 years, less than 65 years at the time of giving informed consent. 2) Those with body mass index from18.5 to 25.0. 3) Those who provided informed consent forparticipation. 4) Those with brown fat activity between 1.0 and 10.0.
Exclusion criteria
Exclusion criteria: 1) Those who have a disorder to absorption, distribution, metabolism, excretion of food, such as digestive tract, liver, kidney, heart and cardiovascular system. 2) Those who have a history of asthma. 3) Those who are allergic to bee products (such as honey), conifers, poplar, peruvian balsam (a resin obtained from pine trees in South America), or salicylic acid (included in anti-inflammatory medicines, therapeutics for wart, corn, etc.) 4) Those who using or being treated with drugs that affect breath analysis, such as hay fever or chronic rhinitis medication. 5) Those with a history of the surgery considerable in the gastrointestinal tract site, for example, gastrectomy, stomach and intestines suturation, intestinal tract resection and so on (Excluding polypectomy and appendectomy). 6) Those who develop food allergies or other symptoms related to the test food, or who develop allergies or other symptoms when taking other supplements. 7) Be Suspected alcohol or drug dependence. 8) Those who meet the diagnostic criteria for metabolic syndrome. 9) Those taking medicines for glucose or lipid metabolism or antihypertensive drugs. 10) Those who routinely consume health foods containing propolis and black ginger, or functional foods and foods with functional claims and influences on lipid metabolism and body fat. 11) Those with a smoking habit of less than 10 years. 12) Those who participated in other clinical trial at resent (last 12 weeks). 13) Those who have donated 400 mL blood within the last 12 weeks, 200 mL blood within the last 4 weeks or component blood donations within the last 2 weeks from the date of consent. 14) Those with irregular lifestyles (e.g. night shift workers). 15) Those who wish to become pregnant, pregnant women or lactating women during the study period. 16) Those who will be taking other dietary supplements during the study period. 17) Those who deemed unsuitable for the study by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cold-induced thermogenesis (difference in oxygen consumption at room temperature of 27 degree and 19 degree) as an index of brown fat activity | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Respiratory quotient 2) Carbohydrate oxidation rate 3) Fat oxidation rate 4) Change in body composition 5) Blood tests 6) Dietary survey | — |
Countries
Japan
Contacts
Public ContactTakuma Hyodo
Yamada Bee Company, Inc. Functional research section, Institute for Bee Products & Health Science R&D department
Outcome results
None listed