Incidence, clinical factors, and endotype characterization of coronary microvascular dysfunction in patients with nonobstructive coronary artery disease undergoing 13N-ammonia positron emission tomography

Incidence, clinical factors, and endotype characterization of coronary microvascular dysfunction in patients with nonobstructive coronary artery disease undergoing 13N-ammonia positron emission tomography - Incidence, clinical factors, and endotype characterization of coronary microvascular dysfunction in patients with nonobstructive coronary artery disease undergoing 13N-ammonia positron emission tomography

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000056324

Enrollment

400

Registered

2024-12-01

Start date

2017-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with suspected or known coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Consecutive individuals with clinical signs or symptoms of ischemic heart disease who underwent myocardial perfusion PET, between January 2017 and April 2024, at our institution.

Exclusion criteria

Exclusion criteria: We excluded 536 patients owing to prior documented myocardial infarction and/or coronary revascularization (n=434) [myocardial infarction (n=210), percutaneous coronary intervention (n=378), or coronary artery bypass grafting (n=93)], known cardiomyopathy (n=46), previous hospitalization for heart failure (n=22), left ventricular ejection fraction <30% (n=15), congenital heart disease (n=9), significant valvular heart disease (n=8), and missing data (n=2). Of the remaining 777 patients, 683 patients underwent anatomical coronary assessments via coronary computed tomography angiography (CCTA), invasive CAG, or both within 6 months of the PET examination; and we excluded 84 patients who did not undergo CCTA or CAG within the 6 months, and 10 patients with inadequate imaging qualities

Design outcomes

Primary

Measure	Time frame
Incidence of CMD and identified clinical factors and PET-related parameters that were associated with a decrease in myocardial flow reserve (MFR).	—

Countries

Japan

Contacts

Public ContactSHIRO MIURA

Sapporo Kojinkai Memorial Hospital Department of Cardiology,

shirotan1027m@yahoo.co.jp08017135544

Outcome results