Bactericidal effect of toothpaste containing silver ion against oral pathogens

Bactericidal effect of toothpaste containing silver ion against oral pathogens - Bactericidal effect of toothpaste containing silver ion against oral pathogens

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000056101

Enrollment

100

Registered

2024-12-10

Start date

2025-02-28

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries, chronic periodontitis, oral candidiasis, opportunistic infections caused by staphylococci

Interventions

Participants will be instructed to use a commercially available silver ion toothpaste (SMILE YOU) freely during their regular brushing routine for a continuous period of 180 days. Participants will be

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Able-bodied persons over 18 years old

Exclusion criteria

Exclusion criteria: Minors, pregnant women, those who have received antimicrobial agents within the past 6 months, those with systemic diseases, and those with xerostomia.

Design outcomes

Primary

Measure	Time frame
Subjects will be randomly assigned to either a group using two toothpastes containing silver ions or a group using a toothpaste without silver ions. To evaluate the bactericidal effect of silver ions, the proportions of various oral pathogens in saliva will be assessed through culture testing on selective media before toothpaste use and at 30, 90, and 180 days after starting use.	—

Countries

Japan

Contacts

Public ContactHidenobu Senpuku

Nihon University School of Dentistry at Matsudo Microbiology and Immunology

senpuku.hidenobu@nihon-u.ac.jp047-6-360-9336

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026