Fungal Endophthalmitis
Conditions
Interventions
None listed
Sponsors
Yokohama City University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Included studies will be case-control, cross-sectional, prospective, or retrospective clinical studies that provide sufficient data on both the sensitivity and specificity of BDG for FE. Original studies must provide sufficient data to calculate at least one of AUC-ROC, DOR, or combined sensitivity and specificity of BDG for diagnosing fungal endophthalmitis. The reference standard is a clinical diagnosis by a physician, and the specimens included in the study will be aqueous humor and vitreous fluid. Sensitivity is defined as the number of true positives divided by the sum of true positives and false negatives, while specificity is defined as the number of true negatives divided by the sum of true negatives and false positives. No age restrictions will be imposed, nor will there be restrictions on publication date. No language restrictions will apply if sufficient data is provided. Both full-length articles and brief reports will be included.
Exclusion criteria
Exclusion criteria: Studies reporting only sensitivity or specificity will be excluded, as this precludes conducting a bivariate meta-analysis. Duplication of data will be avoided and duplicate use will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity, specificity, area under the curve (AUC), and diagnostic odds ratio (DOR) will be evaluated. If a study includes a range of cut-offs, the data point closest to the widely used cut-off of 20 pg/mL for serum BDG on a log scale will be selected for analysis. | — |
Countries
Japan
Contacts
Public ContactYuki Mizuki
Yokohama City University School of Medicine Department of Ophthalmology and Visual Science
Outcome results
None listed