lung cancer
Conditions
Interventions
Enhanced support for coping with side effect during medication counseling and receive a form containing information on coping with side effect after the medication counseling. The contents include pr
Sponsors
Kansai Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) advanced lung cancer patients with no prior chemotherapy 2) planned to receive cisplatin or carboplatin 3) capable of communication and do not have cognitive impairments 4) no known history of central nervous system disease (e.g., brain metastases or a seizure disorder) 5) normal liver and renal function
Exclusion criteria
Exclusion criteria: 1) patients using drugs affecting cortisol (steroids, female hormones, rifampicin, phenytoin, phenobarbital) We do not exclude patients who use dexamethasone as a countermeasure against nausea and vomiting, as it is necessary when using anticancer drugs with high emetogenic risk. 2) patients with serious electrolyte imbalance 3) patients with nausea or vomiting in the 24 hours before enrollment 4) patients who have been treated with antipsychotic agents such as risperidone, quetiapine, clozapine, a phenothiazine, or a butyrophenone within 30 days prior to enrollment or who are planned to receive such treatment during the study period (patients could receive antipsychotic drugs such as olanzapine and prochlorperazine as antiemetic therapy for treatment or prophylaxis) 5) patients with concurrent abdominal radiotherapy 6) patients who are pregnant and lactating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rate of no nausea from day1 to day7 after initial chemotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) CR rate 2) CP rate 3) TC rate 4) salivary cortisol and IgA will be assessed at before intervention and day7 from the initial chemotherapy 5) Brief COPE score 6) EQ-5D-5L score 7) coping implementation or not 8) PHQ-9 score 9) ESAS-r-J score | — |
Countries
Japan
Contacts
Public ContactRyohei Fujii
Kansai Medical University Department of Psychosomatic Medicine
Outcome results
None listed