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The effectiveness and safety of testosterone replacement therapy in the musculoskeletal system of males with hypogonadism: A systematic review and meta-analysis

The effectiveness and safety of testosterone replacement therapy in the musculoskeletal system of males with hypogonadism: A systematic review and meta-analysis - Testosterone replacement therapy in hypogonadism

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000055818
Enrollment
Unknown
Registered
2024-10-12
Start date
2024-10-12
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypogonadism

Interventions

None listed

Sponsors

Teikyo University Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: No restrictions were placed on article types or publication language. To be included, a study had to meet the following criteria: 1) It was a placebo-controlled randomized trial; 2) It involved patients with hypogonadism; and 3) The treatment duration was more than 24 weeks or six months.

Exclusion criteria

Exclusion criteria: Exclusion criteria were: 1) treatment with supplements; 2) not being a randomized controlled trial (RCT); and 3) insufficient data.

Design outcomes

Primary

MeasureTime frame
The primary outcome was the change in body composition.

Secondary

MeasureTime frame
The secondary outcomes included skeletal and muscle function (risk of fracture, handgrip strength, and forearm bone mineral density [BMD]) and metabolism (high-density lipoprotein cholesterol [HDL], low-density lipoprotein cholesterol [LDL], triglycerides [TG], and homeostatic model assessment for insulin resistance [HOMA-R] for patients with type 2 diabetes mellitus [T2DM]).

Countries

Japan,North America

Contacts

Public ContactRyusuke Ochiai

Teikyo University Hospital Department of Oncology

ryo7132003@med.teikyo-u.ac.jp03-3964-1211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026