Exploration and establishment of predictive markers of intravenous glucocorticoids response in active thyroid eye disease

Exploration and establishment of predictive markers of intravenous glucocorticoids response in active thyroid eye disease - Exploration and establishment of predictive markers of intravenous glucocorticoids response in active thyroid eye disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055754

Enrollment

Registered

2025-10-01

Start date

2018-12-25

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thyroid eye disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Cases diagnosed as active thyroid eye disease.

Exclusion criteria

Exclusion criteria: Cases in which the physician in charge considers the patient ineligible for enrollment in the study

Design outcomes

Primary

Measure	Time frame
After 24 weeks, we will search for differentially expressed proteins by comprehensive proteomic using pretreatments sera of responders with CAS improvement (improvement of 2 or more points or decrease to less than 3 points) and other non responders. Once candidate proteins are identified, the number of cases will be increased and the ELISA method will be used for confirmation and validation.	—

Countries

Japan

Contacts

Public ContactKazuhiko Matsuzawa

Tottori University Faculty of Medicine Division of Pharmacology

k.matsuzawa@tottori-u.ac.jp0859-38-6512

Outcome results