Prospective study on the relationship between preoperative chemotherapy and risk of thrombosis in pancreatic cancer

Prospective observational study on the relationship between preoperative chemotherapy and risk of thrombosis in pancreatic cancer - Prospective study on the relationship between preoperative chemotherapy and risk of thrombosis in pancreatic cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055740

Enrollment

120

Registered

2024-10-07

Start date

2024-10-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Pathologically or clinically diagnosed with pancreatic cancer. 2)Patients with resectable or borderline resectable pancreatic cancer who are scheduled for neoadjuvant chemotherapy.

Exclusion criteria

Exclusion criteria: 1)Patients who have a history of thrombosis within 5 years prior to enrollment, or who currently have a thrombosis. 2)Patients with contrast allergies. 3)Patients already taking anticoagulants. 4)Patients with obstructive jaundice or pancreatitis who are not expected to improve.

Design outcomes

Primary

Measure	Time frame
Incidence of thrombosis(after neoadjuvant chemotherapy, perioperative period)	—

Secondary

Measure	Time frame
1)Changes in Tissue factor(TF), Procoagulant activity(PCA), D-dimer and CA19-9 before and after preoperative chemotherapy and after surgery. 2)Relationship between TF, PCA, D-dimer, CA19-9 and the development of thrombosis. 3)Relationship between the efficacy of neoadjuvant chemotherapy and TF, PCA, D-dimer, CA19-9, and the development of thrombosis.	—

Countries

Japan

Contacts

Public ContactMariko Kamiya

Kanagawa Cancer Center Gastrointestinal surgery (Hepato-Biliary-Pancreatic)

kamiya.1c90o@kanagawa-pho.jp045-520-2222

Outcome results