Healthy young adult males
Conditions
Interventions
The participants alternate between low-carb and low-fat days for six days. The combination of the low-carb and low-fat days results in a nutritionally balanced diet based on the Dietary Reference Inta
Sponsors
Fukuoka University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 23.5<BMI<30 Willing and able to consume the provided foods and beverages
Exclusion criteria
Exclusion criteria: Individuals taking regular medications that affect metabolism (e.g., diabetes treatments, alpha-blockers, beta-blockers). Individuals with diseases that affect metabolism (e.g., diabetes, thyroid disorders). Individuals diagnosed with or having a history of mental illness. Individuals using implanted medical devices such as pacemakers. Individuals with severe cardiovascular disease. Individuals with cancer. Individuals with oral or dental diseases, or those undergoing oral or dental treatment. Individuals with a history of gastrointestinal surgery (primarily involving the esophagus, stomach, duodenum, small intestine, colon, or liver; appendectomy is allowed). Individuals with gastrointestinal diseases. Individuals with knee or back conditions that interfere with daily life. Individuals with extremely irregular eating habits (e.g., frequent skipping of meals, picky eating, frequent snacking, or noticeable irregularities in meal times). Individuals participating in or planning to participate in other studies involving the consumption of food, medication intake, or the application of cosmetics or medications. Individuals with an exercise habit (those exercising for 60 minutes or more per day, at least four days per week). Individuals engaged in heavy physical labor in daily life or planning to do so during the study period (such as physically demanding work, prolonged walking, or standing activities). Individuals who regularly consume excessive alcohol (more than 60g of pure alcohol per day) or tobacco, and who cannot abstain from smoking or drinking for three days prior to the testing days during the study period. Individuals with claustrophobia or a subjective fear of confined spaces. Individuals with food allergies. Other individuals deemed unsuitable by the principal investigator (Yoshinari Uehara, Fukuoka University) for the safe execution of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolic flexibility | — |
Secondary
| Measure | Time frame |
|---|---|
| 24-hour blood glucose level urinary metabolome physical activity appetite gut microbiota | — |
Countries
Japan
Contacts
Public ContactYoichi Hatamoto
National Institute of Health and Nutrition National Institutes of Biomedical Innovation, Department of Nutrition and metabolism
Outcome results
None listed