Correlation Between Adverse Events and Gut Microbiota Alterations During Postoperative Adjuvant Chemotherapy for Colon Cancer

Correlation Between Adverse Events and Gut Microbiota Alterations During Postoperative Adjuvant Chemotherapy for Colon Cancer - Correlation Between Adverse Events and Gut Microbiota Alterations During Postoperative Adjuvant Chemotherapy for Colon Cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055664

Enrollment

Registered

2024-11-30

Start date

2024-11-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have provided written consent for participation in this study Patients who are 20 years or older but under 80 years old at the time of consent Patients diagnosed with colon cancer (including appendiceal, cecal, ascending, transverse, descending, or sigmoid colon cancer) who have undergone primary tumor resection Patients diagnosed with Stage III cancer Patients eligible for adjuvant chemotherapy with either capecitabine and oxaliplatin (for 3 or 6 months) or capecitabine (for 6 months)

Exclusion criteria

Exclusion criteria: Patients with rectal cancer Patients who have taken antibiotics orally for more than one week before surgery Patients with severe liver dysfunction or severe renal dysfunction

Design outcomes

Primary

Measure	Time frame
Changes in the intestinal microbiota before and after adjuvant chemotherapy for colon cancer	—

Secondary

Measure	Time frame
Changes in bowel function before and after adjuvant chemotherapy for colon cancer and its correlation with adverse events	—

Countries

Japan

Contacts

Public ContactSohei Akuta

Saitama Medical University International Medical Center Gastrointestinal Surgery

sa46101@5931.saitama-med.ac.jp042-984-4111

Outcome results