The relationship among fructose intake, length of duodenal villi and small intestinal permeability in the patients of metabolic dysfunction-associated steatoic liver disease

The relationship among fructose intake, length of duodenal villi and small intestinal permeability in the patients of metabolic dysfunction-associated steatoic liver disease - Fructose-MASLD study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055620

Enrollment

100

Registered

2024-09-27

Start date

2024-09-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metabolic dysfuction-associated steatotic liver disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) outpatient or hospitalized patients with MASLD, non-NAFLD liver disease, or without liver disease 2) patients who are scheduled to undergo an upper endoscopy for medical purposes within 3 months 3) patients who are able to take dietary questionnaires, duodenal biopsies, and intestinal permeability tests 4) patients giving voluntary written informed concent after sufficient explanation for participation in this study

Exclusion criteria

Exclusion criteria: 1) Patients with abnormalities that are presumed to affect intestinal permeability, such as intestinal inflammation 2) Patients with a history of gastrointestinal surgery other than cholecystectomy or appendectomy 3) Patients with gastrointestinal malignancies 4) Patients with obvious bleeding tendencies or blood clotting abnormalities 5) Other patients who are judged to be inappropriate by the principal investigator or the investigator

Design outcomes

Primary

Measure	Time frame
fructose intake, length of duodenal villi, and small intestinal permeability	—

Countries

Japan

Contacts

Public ContactMasashi Matsushima

Tokai University School of Medicine Internal Medicine (gastroenterology)

mmatsush@tokai.ac.jp0463931121

Outcome results