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The effect of chemical mouthwash on halitosis and oral microbiome in orthodontic patients.

The effect of chemical mouthwash on halitosis and oral microbiome in orthodontic patients: a randomized clinical trial. - The effect of chemical mouthwash on halitosis and oral microbiome in orthodontic patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000055502
Enrollment
32
Registered
2024-09-17
Start date
2025-01-20
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

malocclusion

Interventions

1.The test group uses Mondamin HABITPRO (Earth Chemical, Tokyo, Japan) three times a day (10 ml, 20 seconds, 14 days (2 weeks), morning, noon and evening mouthwash after brushing). 2.Participants are

Sponsors

Tsurumi University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Healthy subjects between 18 and 40 years old. 2.Undergoing orthodontic therapy with fixed appliances both in the upper and lower arch with monthly follow-up appointments. 3.In extraction cases patients could be enrolled at least two months after the last extraction. 4.Total initial VSCs levels above the baseline level of 150 ppb.

Exclusion criteria

Exclusion criteria: Patients with active caries, periodontitis (periodontal pockets 3 mm or more), dental fluorosis/ dysplasia of the teeth, syndromes or other abnormalities of the craniofacial complex, mental problems, subjects smoking or using other tobacco products, taking antibiotics during the last 2 months, use of chlorhexidine or another mouthwash in the last 3 weeks, allergy to cetylpyridinium chloride, and participating in other trials are excluded.

Design outcomes

Primary

MeasureTime frame
Hydrogen sulfide (H2S), Methyl-mercaptan (CH3SH), Dimethyl sulfide ([(CH3)2S])

Countries

Japan

Contacts

Public ContactYudai Shimpo

Tsurumi University Department of Orthodontics, School of Dental Medicine

shinpo-y@tsurumi-u.ac.jp045-580-8438

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026