Analysis of diagnostic criteria for chronic endometritis and endometrial dysbiosis affecting pregnancy outcomes in assisted reproductive technology

Analysis of diagnostic criteria for chronic endometritis and endometrial dysbiosis affecting pregnancy outcomes in assisted reproductive technology - Diagnostic criteria for chronic endometritis and endometrial dysbiosis affecting pregnancy outcomes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055467

Enrollment

100

Registered

2024-10-15

Start date

2024-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Infertile women who have undergone assisted reproductive technology and meet the following conditions (1) Under 40 years old (2) History of one or more implantation failure after embryo transfer (including biochemical pregnancy) (3) No intrauterine disorders after hysteroscopy or hysteroscopic surgery within 1 year (4) hCG <5.0 mIU/mL at the day of pregnancy test (5) No history of treatment for chronic endometritis (6) No use of probiotics or lactoferrin supplements (7) Women who have frozen morphologically good blastocysts (blastocysts without grade C of Gardner's classification) and will perform embryo transfer with their blastocysts in the next cycle

Exclusion criteria

Exclusion criteria: Women without the above diagnostic criteria

Design outcomes

Primary

Measure	Time frame
The number of endometrial CD138 positive cells or the results of microbiome analysis for therapeutic targets	—

Countries

Japan

Contacts

Public ContactSayaka Kitagawa

Sugiyama Clinic Marunouchi Center for Reproductive Medicine and Endoscopy

kuroda@sugiyama.or.jp+81-(0)3-5222-1500

Outcome results