The study for association between peripheral vasoconstrictor response and myocardial diastolic dysfunction in patients with type 2 diabetes

The study for association between peripheral vasoconstrictor response and myocardial diastolic dysfunction in patients with type 2 diabetes - Association between peripheral vasoconstrictor response and myocardial diastolic dysfunction in patients with type 2 diabetes

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055459

Enrollment

Registered

2024-09-09

Start date

2024-09-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients (male or female) between 18 and under 80 years old 2) Inpatients with type 2 diabetes 3) Patients giving consent in writing for participation for this study

Exclusion criteria

Exclusion criteria: 1) Patients with type 1 diabetes, or diabetes caused by other specific mechanistic diseases 2) Patients with diabetes during pregnancy 3) Patients hospitalized due to acute complications of diabetes (DKA, HHS, hypoglycemia, etc.) 4) Patients hospitalized for acute infectious diseases (pneumonia, cellulitis, etc.) 5) Patients hospitalized for cardiovascular diseases (ACS, Af, etc.) 6) Patients with a history of catheterization for cardiovascular diseases within 1 year 7) Patients with a left ventricular ejection fraction (EF) of 40% or less 8) Patients with heart failure symptoms or anginal pain in the resting state 9) Patients on oral beta-blockers 10) Patients with an ABI (ankle brachial pressure index) of less than 0.9 11) Patients with severe hepatic dysfunction 12) Patients with neurological disease presenting with autonomic neuropathy

Design outcomes

Primary

Measure	Time frame
Correlation between index of myocardial diastolic dysfunction and peripheral vasoconstrictor response.	—

Secondary

Measure	Time frame
Correlation of diabetic neuropathy parameters (CVR-R, Schellong test, nerve conduction velocity test, etc.) with myocardial diastolic dysfunction and other cardiac function parameters (BNP, left ventricular ejection fraction, fQRS, etc.). Correlation of cardiac function parameters with clinical indicators of diabetic complications (retinopathy stage, urinary albumin, eGFR, etc.). Blood test: NT-proBNP, high-sensitivity CRP, TNF-alpha, IL-6, total PAI-1, Renin, Aldosterone, Adrenaline, Noradrenaline, Dopamine, Eotaxin, HMW (high molecular weight)-adiponectin, MLC (myosin light chain)-1, etc. Vascular endothelial function test: End-PAT Peripheral vasoconstriction response: laser doppler flowmetry Electrocardiography: fQRS, CVR-R, etc. Evaluation of peripheral arterial disease: ABI (ankle brachial index) Echocardiography: GLS, E/e, E/A, DcT, etc.	—

Measure

Time frame

Correlation of diabetic neuropathy parameters (CVR-R, Schellong test, nerve conduction velocity test, etc.) with myocardial diastolic dysfunction and other cardiac function parameters (BNP, left ventricular ejection fraction, fQRS, etc.). Correlation of cardiac function parameters with clinical indicators of diabetic complications (retinopathy stage, urinary albumin, eGFR, etc.). Blood test: NT-proBNP, high-sensitivity CRP, TNF-alpha, IL-6, total PAI-1, Renin, Aldosterone, Adrenaline, Noradrenaline, Dopamine, Eotaxin, HMW (high molecular weight)-adiponectin, MLC (myosin light chain)-1, etc. Vascular endothelial function test: End-PAT Peripheral vasoconstriction response: laser doppler flowmetry Electrocardiography: fQRS, CVR-R, etc. Evaluation of peripheral arterial disease: ABI (ankle brachial index) Echocardiography: GLS, E/e, E/A, DcT, etc.

—

Countries

Japan

Contacts

Public ContactShintaro Sakurai

Dokkyo Medical University Department of Endocrinology and Metabolism

ssakurai@dokkyomed.ac.jp028-287-2150

Outcome results