Healthy Japanese
Conditions
Interventions
Duration: Eight weeks Test food: Sea buckthorn juice Administration: Take 30 mL daily after breakfast, diluted 3~4 times with water because of its strong acidity. *If you forget to take the test
Sponsors
ORTHOMEDICO Inc.
Hiroo Dermatology Clinic &
Mentors inc. Medical Corporation Seishinkai, Takara Clinic Nerima Medical Association, Minami-machi Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Japanese 2. Men or women 3. Individuals aged 30 or more and less than 60 4. Healthy individuals 5. Individuals whose TEWL is 15.1 g/h/m2 or more at screening (before consumption)
Exclusion criteria
Exclusion criteria: Individuals who 1. are undergoing medical treatment or have a medical history of malignant tumor, heart failure, or myocardial infarction 2. have a pacemaker or an implantable cardioverter defibrillator (ICD) 3. are currently undergoing treatment for any of the following chronic diseases: cardiac arrhythmia, liver disorder, chronic kidney disease, cerebrovascular disorder, rheumatic disease, diabetes mellitus, dyslipidemia, hypertension, or any other chronic diseases 4. are taking "Foods for Specified Health Uses" or "Foods with Functional Claims" 5. are taking or using medications (including herbal medicines) and supplements 6. are allergic to medicines and foods related to the test products, particularly who show allergic reactions to peach, apple, orange, milk, or soybean 7. are pregnant, lactating, or planning to become pregnant during this study 8. have been enrolled in other clinical studies within the last 28 days before the agreement to participate in this study or plan to participate in another study during this study 9. have been diagnosed with atopic dermatitis 10. habitually receive skincare treatment (such as aesthetic treatment) or use instruments for beauty treatment (such as facial treatment device) 11. have undergone cosmetic surgery 12. usually take food/beverage containing functional ingredients which may influence skin (such as gamma-aminobutyric acid (GABA), isoflavones, lactic acid bacteria, bifidobacteria, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), astaxanthin, glucosylceramide, proteoglycans, piceatannol, lycoperosides, collagen peptide) 13. usually drink to excess (average of more than about 20 g/day as absolute alcohol intake) {500 mL: a medium bottle of beer or about 1.5 cans of canned chu-hi, 180 mL: about 1.5 glasses of wine, 90 mL: half-go of shochu, 60 mL: a glass of whiskey brandy (double)} 14. are judged as ineligible to participate in this study by the physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The measured value of transepidermal water loss (TEWL) at eight weeks after consumption (8w) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The measured value of TEWL at four weeks after consumption (4w) 2. The measured values of viscoelasticity of skin (R0~R9) at 4w and 8w 3. The measured values of moisture content of skin surface at 4w and 8w 4. The measured values of "my skin is glowing," "my skin is less prone to rough," "my skin is resilient," "my skin condition is good," "pores are less visible," "my skin is fine," "my skin tone is lighter," "spots are less noticeable," "my skin has firmness," and "my skin has no dullness" at 4w and 8w 5. The measured values of biological antioxidant potential (BAP), diacron-reactive oxygen metabolite (d-ROMs), and superoxide dismutase (SOD) at 4w and 8w 6. The measured values of erythropoietin at 4w and 8w | — |
Countries
Japan
Contacts
Public ContactNaoko Suzuki
ORTHOMEDICO Inc. R&D Department
Outcome results
None listed