Transitory hyperosmotic laxative effect
Conditions
Interventions
Oral ingestion. Control (reference) test substance (nondigestible oligosaccharide) 5 g. In the case of transitory hyperosmotic laxative induction, the continuation of the test for ingestion of the c
Sponsors
Jumonji University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Normal, adult 2. Japanese
Exclusion criteria
Exclusion criteria: A person who 1. has a history of gastrointestinal diseases or diseases 2. often develops diarrhea 3. has food allergies (especially milk and dairy products) 4. has impaired glucose tolerance, such as diabetes mellitus 5. has carbohydrate-related metabolic diseases (especially lactose intolerance) 6. taking antibacterial agents or regularly using laxatives 7. has a history of malignancy or heart disease, or are undergoing treatment 8. BMI of 30 or more, or less than 17 9. had participated in other clinical trials in the 28 days prior to submission of consent to this study 10. smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum dose of intake of oligosaccharide syrup that does not induce transitory hyperosmotic laxative effect, observation of laxative effect. | — |
Secondary
| Measure | Time frame |
|---|---|
| Defecation status, gastrointestinal symptoms and breath hydrogen gas excretion associated with ingestion of the test substance. | — |
Countries
Japan
Contacts
Public ContactSadako Nakamura
Jumonji University Graduate School of Human Life Sciences/ Dept. Food Science, Faculty of Human Life
Outcome results
None listed