Family Association and Reliable Predicting Factors for Treatment-Resistant Depression: A 10-Month Follow-Up Study

Family Association and Reliable Predicting Factors for Treatment-Resistant Depression: A 10-Month Follow-Up Study - FARPFTRD: A 10-Month FUS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000055330

Enrollment

200

Registered

2024-08-25

Start date

2022-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

By collecting clinical and physiological data (including inflammation factors, EEG and brain resting functional MRI) from the family members of TRD and non-TRD cases, we aim to find reliable predictors of treatment-resistant depression (TRD) to facilitate accurate diagnosis and treatment planning for TRD patients.

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients are eligible for the study if they are adults (aged between 21 and 70 years) and are diagnosed with MDD based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. MDD diagnoses are established after a thorough medical history is taken and the semi-structured Mini International Neuropsychiatric Interview (American Psychiatric Association, 1994) is conducted. Patients' FDR, including parents, siblings, and children, will be interviewed for psychiatric comorbidities.

Exclusion criteria

Exclusion criteria: Patients are excluded if they have a lifetime psychiatric history of psychotic disorders, bipolar disorder, or organic mental disorder, or if they have a lifetime medical history of major systemic illness or neurological disorder (e.g., stroke, seizure, traumatic brain injury, or post-brain surgery).

Design outcomes

Primary

Measure	Time frame
Identify the variables that are most predictive of the participants' total MSM and TRDSS score.	—

Secondary

Measure	Time frame
1.TRD patients vs. non-TRD patients: have more family members with psychiatric comorbidities, especially TRD. 2.TRD patients vs. non-TRD patients: worse clinical outcomes during follow-up 3.TRD patients vs. non-TRD patients vs. family members: more likely to develop bipolar symptoms and dementia symptoms during follow-up 4.Identify good clinical predictors for MSM and TRDSS. 5.Identify good prediction models using EEG and MRI for MDD and TRD. We would like to develop a new prediction model based on the results from our study.	—

Measure

Time frame

1.TRD patients vs. non-TRD patients: have more family members with psychiatric comorbidities, especially TRD. 2.TRD patients vs. non-TRD patients: worse clinical outcomes during follow-up 3.TRD patients vs. non-TRD patients vs. family members: more likely to develop bipolar symptoms and dementia symptoms during follow-up 4.Identify good clinical predictors for MSM and TRDSS. 5.Identify good prediction models using EEG and MRI for MDD and TRD. We would like to develop a new prediction model based on the results from our study.

—

Countries

Asia(except Japan)

Contacts

Public ContactJia-Shyun Jeng

Taipei Veterans General Hospital, Taipei, Taiwan Department of Psychiatry

arieljeng@gmail.com88628757027

Outcome results