Healthy adult
Conditions
Interventions
Onsen bathing for 4 times during a 2-week period
Sponsors
Kyushu University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Recruitment Targeting Beppu City Hall Employees and Residents in the Vicinity of Beppu City 1) who have provided written consent voluntarily. 2) aged 18 and above but below 70 at the time of consent acquisition, regardless of gender. 3) who have not been diagnosed with chronic illnesses. 4) who have not bathed in hot springs in the 14 days prior to assignment. - Artificial hot springs are also considered as hot spring bathing and are excluded. - Bathing with ordinary tap water is not exempted.
Exclusion criteria
Exclusion criteria: 1) Individuals with a history of hypersensitivity to hot springs. 2) who have taken medication (such as antibiotics, intestinal regulators, laxatives, etc.) that may affect the test one month before the pre-examination, or those who plan to take such medication during the test period. 3) with a history of appendix removal. 4) who have undergone surgery in the six months prior to obtaining consent, which is considered to have an impact on the test (such as colonoscopy, gallstone or gallbladder removal, gastric bypass surgery, etc.). 5) who are expected to undergo significant changes in their living environment, such as moving or job relocation, during the test period. 6) with an extremely irregular dietary lifestyle. 7) Heavy alcohol drinkers. 8) with a history of and current serious illnesses in the heart, liver, kidneys, digestive system, etc. 9) who are pregnant, breastfeeding, or have the intention to become pregnant during the test period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity of the gut microbiota, Occupancy of the gut microbiota, Changes in concentration of fecal metabolites (short-chain fatty acids) | — |
Secondary
| Measure | Time frame |
|---|---|
| Analysis of the gut microbiota (next generation-targeted amplicon sequencing), fecal metabolites concentration, and subjective evaluation questionnaire (defecation, quality of life, physical conditions) | — |
Countries
Japan
Contacts
Public ContactMidori Takeda
Kyushu University Urban Institute
Outcome results
None listed