Effect of flumazenil administration on nausea and vomiting after oral surgery

Effect of flumazenil administration on nausea and vomiting after oral surgery - Effect of flumazenil administration on nausea and vomiting after oral surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000055097

Enrollment

Registered

2024-08-01

Start date

2024-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

jaw deformity

Interventions

Flumazenil group will receive 0.2mg(2mL) of flumazenil after remimazolam anesthesia. Flumazenil non-treatment group will receive 2mL of saline after remimazolam anesthesia.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing orthognathic surgery ASA-PS 1-2 Patient who gave consent for this study

Exclusion criteria

Exclusion criteria: <20 or >50 years of age, ASA-PS 3 or higher, patient who did not give consent for this study,use of antiemetics or benzodiazepines within 24 h before surgery, contraindicated for administration of medications used in this study, emergency surgery

Design outcomes

Primary

Measure	Time frame
Incidence of PONV (early period: within 2 hours after the end of anesthesia, late period: 2 - 24 hours after the end of anesthesia)	—

Secondary

Measure	Time frame
Patient background (age, sex, height, weight, smoking history, and presence or absence of motion sickness/ PONV) surgical and anesthetic factors (operation name, operation time, anesthesia time, total infusion volume, blood loss, intraoperative opioid use, and postoperative opioid use) speed of awakening (time from study drug administration to extubation and MOAA/S score to 5) degree of PONV (maximum Numerical Rating Scale (NRS) value), presence or absence of vomiting up to 24 hours after the end of anesthesia, number of ondansetron and metoclopramide doses administered Quality of postoperative recovery (QoR-40)	—

Measure

Time frame

Patient background (age, sex, height, weight, smoking history, and presence or absence of motion sickness/ PONV) surgical and anesthetic factors (operation name, operation time, anesthesia time, total infusion volume, blood loss, intraoperative opioid use, and postoperative opioid use) speed of awakening (time from study drug administration to extubation and MOAA/S score to 5) degree of PONV (maximum Numerical Rating Scale (NRS) value), presence or absence of vomiting up to 24 hours after the end of anesthesia, number of ondansetron and metoclopramide doses administered Quality of postoperative recovery (QoR-40)

—

Countries

Japan

Contacts

Public Contactrie katou

Tokyo Dental College Dental Anesthesiology

rkubota@tdc.ac.jp03-6380-9001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026