Heart failure and persistent atrial fibrillation patients without type-2 diabetes
Conditions
Interventions
Treatment arm: patients were to receive sodium-glucose cotransporter 2 inhibitors (SGLT2is) for more than one month prior to catheter ablation and were continued during 1-year follow-up.
Control arm:
Sponsors
Fujita Health University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The inclusion criteria are as follows and patients who met all inclusion criteria were eligible: patients with PeAF who were referred to our outpatient department; patients with clinical symptoms, history, and findings that suspect HF based on the Japanese Circulation Society Guideline; patients with 400 pg/ml or more of the serum N-terminal prohormone of brain natriuretic peptide NT-proBNP levels for diagnosing HF.
Exclusion criteria
Exclusion criteria: Exclusion criteria are as follows: patients who required emergency hospitalization at referral. patients with previously diagnosed structural heart disease, cardiac sarcoidosis, and severe valvular heart disease; patients with very severe HF who were classified into New York Heart Association (NYHA) functional class IV. patients who had potential risk of the drug adverse effect of SGLT2is (dehydration, genital infections, etc. patients under 18 years old and those who were pregnant; patients with creatinine clearance (calculated by Cockcroft-Gault formula) <30 mL/min and those on hemodialysis; patients who had LA appendage thrombus on transesophageal echocardiography before the procedure; patients with mechanical valves; patients with already-diagnosed T2DM who took hypoglycemic medications; patients who were diagnosed with T2DM at enrollment (HbA1c: 6.5% or more) patients who took SGLT2is for HF treatment before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Atrial tachyarrhythmia events during 1-year follow-up after catheter ablation 2. Death/Heart hospitalization | — |
Countries
Japan
Contacts
Public ContactMasahide Harada
Fujita Health University Department of Cardiology
Outcome results
None listed